Cutting Edge: Secondary Lymphoid-Tissue

Cutting Edge Cutting Edge: Acute Lung Allograft Rejection Is Independent of Secondary Lymphoid Organs

It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung t...

Cutting Edge: Secondary Lymphoid Organs Are

Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturation.

T cell development, originally thought to be completed in the thymus, has recently been shown to continue for several weeks in the lymphoid periphery. The forces that drive this peripheral maturation are unclear. The use of mice transgenic for GFP driven by the RAG2 promoter has enabled the ready identification and analysis of recent thymic emigrants. Here, we show that recent thymic emigrant m...

Lymphoid Organs Occupy Frontline Niches in Secondary Cutting Edge: Resident Memory CD8 T Cells

Cutting edge: Acute lung allograft rejection is independent of secondary lymphoid organs.

It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung t...